Utilize este identificador para referenciar este registo: http://hdl.handle.net/20.500.12253/475
Título: Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
Autores: Duarte, N
Járdánházy, A
Ramalhete, Cátia
Molnar, J
Ferreira, MJU
Palavras-chave: Diterpenes
Epirubicine
Cancer
Data: 2007
Citação: International Congress and 55th Annual Meeting of the Society for Medicinal Plant Research
Resumo: The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.
URI: http://hdl.handle.net/10884/475
Aparece nas colecções:A CS/CN - Comunicações a Conferências

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