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http://hdl.handle.net/20.500.12253/475| Title: | Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
| Authors: | Duarte, N Járdánházy, A Ramalhete, Cátia Molnar, J Ferreira, MJU |
| Keywords: | Diterpenes Epirubicine Cancer |
| Issue Date: | 2007 |
| Citation: | International Congress and 55th Annual Meeting of the Society for Medicinal Plant Research |
| Abstract: | The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated. |
| URI: | http://hdl.handle.net/10884/475 |
| Appears in Collections: | A CS/CN - Comunicações a Conferências |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2007_Graz_Latiranos_MDR.pdf | 617.24 kB | Adobe PDF | View/Open |
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